Missing I²C pull-ups
The I²C bus lines lack pull-up resistors (R5 and R16 are series resistors, not pull-ups).
→ Add two 4.7 kΩ pull-ups on SDA and SCL, e.g.:

No CAN bus termination
The CAN transceiver U7 has only a series resistor R6 on CAN_H. There is no 120 Ω termination across CAN_H/CAN_L.
→ Add a 120Ω Resistor between CAN_H and CAN_L.

No RS-485 termination or failsafe
The RS-485 transceiver U5 has no 120 Ω termination resistor between A and B and no bias resistors for failsafe.
→ Add a 120Ω Resistor across A/B, plus two 4.7k Resistor bias resistors (pull-up on A, pull-down on B).

Shared RESET/EN net
R29 pulls up together:

Local decoupling missing on level translator
U1 (TXS0102) needs a 0.1 µF cap on both VCCA and VCCB, placed close to its pins.
→ Add two 100 nF Capacitor.

Decoupling missing on CAN and RS-485 transceivers
Neither U7 nor U5 have a local bypass capacitor.
→ Place a 100 nF Capacitor adjacent to each VCC pin.

LDO decoupling values
U6 (AMS1117-3.3) has C3/C4 = 22 µF (6.3 V) and C6 = 10 µF. The datasheet calls for 10 µF minimum. Using 22 µF is acceptable, but ensure the voltage rating ≥ 10 V.

LED current-limits
LED1 channels each have series resistors R1, R4, R17. Verify their values suit your target LED current.

Star-ground recommended
Multiple ground portals are scattered across the schematic. For best noise performance, tie all analog/digital ground returns to a single star-point.

Power‐rail annotations
Clearly label 5 V vs. 3.3 V rails (instead of generic net names) so decoupling and protection components are unambiguous.

Unnamed nets
Many nets show as “Net 1”, “Net 4”, etc. Replace with descriptive labels (e.g. “SPI_SCK”, “VBUS_IN”) for readability.

RouteBranchPoint clutter
The “RouteBranchPoint” symbols add visual noise. Use junction dots on multi-pin nets or explicit net labels instead.

Consistent net naming
Ensure all connectors, modules, and ports use the same net names across the schematic (e.g. CAN_H, CAN_L, SDA, SCL) to avoid confusion.