Fresh-place the entire Pico Macro Keyboard PCB from scratch on a 100 mm × 100 mm rounded-rectangle 4-layer board.
Top side priority:

Keep the top side clean and user-facing.
Place the mechanical key switches in a regular macro-keypad grid with consistent row/column spacing and aligned orientation.
Keep the RGB LEDs visually associated with their corresponding switches and avoid crowding the key grid.
Place rotary encoders and any user-facing controls on the top side in ergonomic positions near the key grid.
Place mounting holes near the board corners and keep them clear of switches and encoders.
Bottom side priority:

Place the Raspberry Pi Pico / MCU module and the majority of supporting electronics on the bottom side.
Group the MCU, flash, crystal/oscillator, regulator/power parts, reset/boot circuitry, USB/support passives, and decoupling capacitors by function.
Keep decoupling capacitors close to their associated IC power pins, crystal/load caps close to the MCU oscillator pins, and power components clustered together.
Minimize estimated routing distance between the bottom-side MCU and the top-side switches, LEDs, and encoders.
Prefer moving support passives on the bottom side rather than contaminating the top-side visual layout.
Placement quality goals:

Resolve overlaps, keep all components inside the board outline, preserve routing channels between the key grid and MCU area, and maintain clean edge/corner clearance.
Use both layers intentionally: top for human-interface components, bottom for dense electronics.
After placement, run DRC/review and report any remaining overlap, off-board, or layer-assignment issues.