Done. Removed the old U3 and R19, added a fresh U3 TXS0102DCTR, restored its SDA/SCL, power, OE, and GND connections, and placed it back in the interface cluster near J1/J2 and the related resistors.
Note: R19 is now removed, so the SDA_5V pull-up is gone; SCL_5V still has R20. The focused check did not report U3/R19-related issues, but the broader project may still have the previous layout/routing issues.