You’re right to ask. The exact sequence should be: inspect current layout state → remove any stale/partial routing if present → rerun placement with explicit constraints → review placement for overlaps/off-board parts → run routing → review for remaining airwires/DRC issues.
What has gone wrong historically: one routing attempt found a solution but timed out while applying it, leaving no routed traces; one placement/routing attempt was interrupted while I was resolving setup/constraint state; and earlier placement passes were technically valid but aesthetically unsatisfactory. The safer next run is to treat placement as fresh, verify the board size and routing state first, then route only after confirming the new placement applied cleanly.